📰 Nature.com

In vivo conformational space and defects of misfolded CFTR variants by covalent protein painting

In vivo conformational space and defects of misfolded CFTR variants by covalent protein painting

Protein misfolding drives many diseases, but detecting and characterizing misfolding in living cells remains challenging. Here, the authors apply an in vivo structural method to uncover how Cystic Fibrosis-causing CFTR variants misfold, respond to current the…


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Zdroj: 📰 Nature.com